How can I avoid the challenges while using Salesforce 1 to enhance the mobile-friendly layout?

 In the context of Salesforce, if your aim to enhance the mobile-friendly layout in Salesforce 1, then should follow the following points which are given below:-

Use responsive designC

Try to utilize the responsive design principles with CSS media queries so that you can adapt the layout based on the sizes of the screen of devices.

Considering compact layouts

Try to design a compact page layout to optimize space utilization on even smaller screens.

Utilize flexibility with lightning components

Try to develop lightning components and try to include responsive design in it to create a flexible and dynamic user interface.

Responsive page layout

Ensure that your page layout should be responsive so that you can adjust the fields and sections based on the screen size of the various devices.

Here is the coding given which might be involved in using media queries in CSS:-

/* Example CSS media query for responsive design */

@media only screen and (max-width: 600px) {

    /* Styles for smaller screens */

}

You can also implement a lightning component with even responsive design:-